作者：赵思维，曹晓红

单位：

1.030000山西省太原市，山西医科大学 2.032200山西省汾阳市，山西省汾阳医院 山西医科大学附属汾阳医院老年医学科 通信作者：曹晓红，E-mail：caoxhong@sina.com

单位（英文）：

1.Shanxi Medical University, Taiyuan 030000, China 2.Department of Geriatrics, Shanxi Fenyang Hospital/Fenyang Hospital Affiliated to Shanxi Medical University, Fenyang032200, China Corresponding author: CAO Xiaohong, E-mail: caoxhong@sina.com

关键词：

慢性阻塞性肺疾病; 慢性阻塞性肺疾病稳定期; 药物疗法; 吸入性药物; 非吸入性药物; 靶向制剂; 综述;

关键词（英文）：

Chronic obstructive pulmonary disease; Stable chronic obstructive pulmonary disease; Drug therapy;Inhalation drugs; Non-inhalation drugs; Targeting preparation; Review

中图分类号：

DOI：

10.12114/j.issn.1008-5971.2022.00.152

基金项目：

摘要：

慢性阻塞性肺疾病(COPD)是一种引起气流受限进行性不完全可逆的慢性呼吸道疾病,患者肺功能逐渐恶化,引起进行性呼吸困难,导致一系列器官功能障碍。随着疾病进展及急性加重次数增多,患者肺功能逐渐恶化,致使后期治疗难度增大、治疗效果欠佳、合并症增多、生活质量下降、社会经济负担增加。因此如何预防或减少慢性阻塞性肺疾病稳定期(SCOPD)患者急性加重以及改善患者临床症状是主要治疗目标。本文简述了SCOPD治疗药物的种类,包括吸入性药物、非吸入性药物、靶向药物及其相关机制,以期为临床医师提供个体化规范化药物治疗思路及寻找新的药物治疗靶点提供借鉴。

英文摘要：

【Abstract】　Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that causes airflow limitationprogressive incomplete reversible. The lung function gradually deteriorates, resulting in progressive dyspnea and a series oforgan dysfunction. As the disease progresses and the number of acute exacerbations increases, the pulmonary function of patientsgradually deteriorates, resulting in increased difficulty of late treatment, poor effect, increased complications, decreased qualityof life, and increased social and economic burden. Therefore, how to prevent or reduce acute exacerbation and improve clinicalsymptoms in patients with stable chronic obstructive pulmonary disease (SCOPD) is an main therapeutic target. This paper brieflydescribes the types of drug therapy for patients with SCOPD, including inhalation drugs, non-inhalation drugs, targeted drugs andtheir related mechanisms, so as to provide reference for clinicians to provide individualized and standardized drug treatment ideasand find new drug treatment targets.

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