2020 年4 期 第28 卷
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婴儿痉挛症的治疗研究进展
Research progress on treatment of infantile spasms
作者:陈晓青,董琰
- 单位:
- 063000 河北省唐山市,华北理工大学附属唐山市妇幼保健院小儿神经内科;通信作者:董琰,E-mail:dongyan012000@126.com
- 关键词:
- 痉挛,婴儿;促肾上腺皮质激素;氨己烯酸;治疗;综述
- 关键词(英文):
- Spasms,infantile;Adrenocorticotropic hormone;Vigabatrin;Therapy;Review
- 中图分类号:
- R 742.1
- DOI:
- DOI:10.3969/j.issn.1008-5971.2020.04.003
- 基金项目:
摘要:
婴儿痉挛症(IS)是一种特殊的年龄依赖性癫痫性脑病,以短暂的对称的轴向肌肉(颈部、躯干和/或四肢)收缩为主要特征,常成串发作。IS 可导致精神运动发育障碍,且治疗前准备时间越长则预后越差,因此其一经诊断则应尽快治疗。目前,IS 的治疗主要涉及一线治疗药物、二线治疗药物、新兴药物、生酮饮食及手术治疗等。本文主要综述了 IS 治疗方面的研究进展。
英文摘要:
Infantile spasms(IS),a special age-dependent epilepsy encephalopathy,mainly characterized bytransient symmetrical axial muscle(such as neck,torso and/or limbs)contractions,which usually performed as a series ofseizures. IS may lead to psychomotor developmental disorder,as many studies showed that,the longer preparation time beforetreatment,the worse prognosis of IS,thus it should be treated as soon as possible after diagnosis of IS. Treatment of IS mainlyinvolved first-line therapeutic drugs,second-line therapeutic drug,emerging drugs,ketogenic diet and surgery at present.This paper mainly reviewed the research progress on treatment of IS.
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