作者：陈诗恺1 ，瞿晨芸1 ，宋慧文2

单位：

1.201801上海市，上海交通大学医学院附属瑞金医院检验科　2.201899上海市，上海健康医学院附属嘉定 区中心医院心内科

Units：

1.Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China 2.Department of Cardiology, Jiading District Central Hospital, Shanghai University of Medicine and Health Sciences, Shanghai 201899, China

关键词：

体格检查；铜蓝蛋白；男人；血脂；相关性分析

Keywords：

Physical examination; Ceruloplasmin; Men; Blood fat; Correlation analysis

CLC：

R 446.9

DOI：

10.12114/j.issn.1008-5971.2024.00.062

Funds：

国家自然科学基金资助项目（82070256）；上海市嘉定区自然科学基金资助项目（JDKW-2023-0053）

摘要：

目的　分析不同年龄段男性体检者血清铜蓝蛋白（CP）水平及其与血脂指标〔三酰甘油（TG）、总 胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平〕的相关性。方法　选取2022 年7月—2023年6月于上海健康医学院附属嘉定区中心医院体检中心进行体检的男性 1 325 例为研究对象。根据年龄将 研究对象分为儿童组（1～13岁， n=40）、青少年组（14～19岁，n=55）、中青年组（ 20 ～59岁，n=828）、老年组 （60～95岁，n=402）。比较四组血清CP、TG、TC、HDL-C、LDL-C水平，采用Pearson相关分析探讨四组血清CP水 平与血脂指标的相关性。结果　青少年组、中青年组、老年组血清CP水平低于儿童组，老年组血清CP水平高于青少 年组、中青年组（P＜0.05）；中青年组、老年组血清TG水平高于儿童组（P＜0.05）；中青年组、老年组血清TC水平 高于儿童组、青少年组，老年组血清TC水平低于中青年组（P＜0.05）；青少年组血清HDL-C水平高于儿童组、中青 年组、老年组，老年组血清HDL-C水平低于儿童组、高于中青年组（P＜0.05）；青少年组血清LDL-C水平低于儿童 组，中青年组、老年组血清LDL-C水平高于儿童组、青少年组，老年组血清LDL-C水平低于中青年组（P＜0.05）。儿 童组血清CP水平与血清TG水平呈负相关（P＜0.05），与血清TC、HDL-C、LDL-C水平无直线相关关系（P＞0.05）； 青少年组血清CP水平与血清TC、LDL-C水平呈正相关（P＜0.05），与血清TG、HDL-C水平无直线相关关系 （P＞0.05）；中青年组血清CP水平与血清TG、TC、LDL-C水平呈正相关，与血清HDL-C水平呈负相关（P＜0.05）； 老年组血清CP水平与血清TG、TC、HDL-C、LDL-C水平无直线相关关系（P＞0.05）。结论　不同年龄段男性体检者 血清CP水平不同，其中儿童血清CP水平最高、老年人血清CP水平次之、青少年与中青年血清CP水平相似；且儿童、 青少年、中青年血清CP水平与血脂指标存在相关性，而老年人血清CP水平与血脂指标无直线相关关系。

Abstract：

Objective To analyze the serum ceruloplasmin (CP) levels and their correlation with blood lipid indexes [triglycerides (TG) , total cholesterol (TC) , high-density lipoprotein cholesterol (HDL-C) , and low-density lipoprotein cholesterol (LDL-C) levels] in male physical examination population of different ages. Methods A total of 1 325 males who underwent physical examinations at the Medical Examination Center of Jiading District Central Hospital, Shanghai University of Medicine and Health Sciences from July 2022 to June 2023 were selected as the research subjects. According to age, the study subjects were divided into children group (1-13 years old, n=40) , adolescents group (14-19 years old, n=55) , young and middle-aged group (20-59 years old, n=828) , and elderly group (60-95 years old, n=402) . Serum levels of CP, TG, TC, HDL-C and LDL-C were compared among the four groups. Pearson correlation analysis was used to investigate the correlation between serum CP level and blood lipid indexes in four groups. Results The serum CP level in adolescent group, young and middle-aged group and elderly group was lower than that in children group, and the serum CP level in elderly group was higher than that in adolescent group and young and middle-aged group (P < 0.05) . Serum TG levels in young and middle-aged group and elderly group were higher than those in children group (P < 0.05) . The serum TC level in the young and middle-aged group and elderly group was higher than that in the children group and adolescents group, and the serum TC level in the elderly group was lower than that in the young and middle-aged group (P < 0.05) . The serum HDL-C level in the adolescent group was higher than that in the children group, the young and middle-aged group and the elderly group, and the serum HDL-C level in the elderly group was lower than that in the children group and higher than that in the young and middle-aged group (P < 0.05) . The serum LDL-C level of adolescent group was lower than that of children group, the serum LDL-C level of young and middle-aged group and elderly group was higher than that of children group and adolescents group, and the serum LDL-C level of elderly group was lower than that of young and middle-aged group (P < 0.05) . In children group, serum CP level was negatively correlated with serum TG level (P < 0.05) , but had no linear correlation with serum TC, HDL-C, LDL-C level (P > 0.05) . In adolescents group, serum CP level was positively correlated with serum TC and LDL-C levels (P < 0.05) , but had no linear correlation with serum TG and HDL-C levels (P > 0.05) . In young and middle-aged group, serum CP level was positively correlated with serum TG, TC and LDL-C level, and negatively correlated with serum HDL-C level (P < 0.05) . There was no linear correlation between serum CP level and serum TG, TC, HDL-C, LDL-C level in the elderly group (P > 0.05) . Conclusion The serum CP level of male physical examination population of different ages was different, among which the serum CP level of children was the highest, the serum CP level of the elderly was the second, and the serum CP level of adolescents and young and middle-aged adults was similar. And serum CP levels in children, adolescents and young and middle-aged adults are correlated with blood lipid indexes, while there is no linear correlation between serum CP levels and blood lipid indexes in the elderly.

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