作者：梁方圆，陆景坤，王跃武

单位：

1.010080内蒙古自治区呼和浩特市，内蒙古医科大学药学院　2.010050内蒙古自治区呼和浩特市，内蒙古医科大学基础医学院

单位（英文）：

1.School of Pharmacy, Inner Mongolia Medical University, Hohhot 010080, China2.School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010050, China

关键词：

动脉粥样硬化；胃肠道微生物群；氧化三甲胺；治疗；综述

关键词（英文）：

Atherosclerosis; Gastrointestinal microbiome; Trimethylamine-N-oxide; Therapy; Review

中图分类号：

R 543.5

DOI：

10.12114/j.issn.1008-5971.2023.00.184

基金项目：

国家自然科学基金地区项目（ 81960757，82260813）；内蒙古自治区科技成果转化专项项目（2019CG042）

摘要：

动脉粥样硬化（AS）是心血管疾病的主要病理基础，是冠心病、脑梗死、周围性血管病发生的主要原因。近年研究发现，肠道菌群在心血管疾病的发生过程中具有重要影响，而氧化三甲胺（TMAO）是其主要代谢产物。本文主要综述了TMAO与AS的关系、TMAO促进AS的机制及基于TMAO的AS防治策略，并发现TMAO主要通过影响胆固醇代谢、促进血管炎症反应、促进巨噬细胞泡沫化及影响血小板功能等途径导致AS；同时，减少TMAO形成途径和改变肠道菌群结构可减少TMAO生成，进而对AS的防治起到一定作用。

英文摘要：

Atherosclerosis (AS) is the main pathological basis of cardiovascular disease and the main cause ofcoronary heart disease, cerebral infarction and peripheral vascular disease. Recent studies have found that intestinal flora hasa significant impact on the occurrence of cardiovascular diseases, and trimethylamine-N-oxide (TMAO) is its main metabolite.This article mainly reviews the relationship between TMAO and AS, the mechanism of TMAO in promoting AS and the preventionand treatment strategies of AS based on TMAO. It is found that TMAO causes AS mainly by affecting cholesterol metabolism,promoting vascular inflammation response, promoting macrophage foaming and affecting platelet function. At the same time,reducing the formation pathway of TMAO and changing the structure of intestinal flora can reduce the formation of TMAO, whichplays a certain role in the prevention and treatment of AS.

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