作者：霍迎新，张瑶，赵伟，唐荣杰，廉秋芳

单位：

1.712000陕西省咸阳市，延安大学咸阳医院心血管内科　2.716000陕西省延安市，延安大学医学院

单位（英文）：

1.Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang 712000, China 2.Medical School of Yan'an University, Yan'an 716000, China

关键词：

高血压；H型高血压；中性粒细胞/淋巴细胞比值；臂踝脉搏波传导速度

关键词（英文）：

Hypertension; H-type hypertension; Neutrophil to lymphocyte ratio; Brachial-ankle pulse wave velocity

中图分类号：

R 544.1

DOI：

10.12114/j.issn.1008-5971.2023.00.251

基金项目：

国家自然科学基金地区科学基金项目（82160090）；陕西省卫生健康科研基金项目（2021C003）；咸阳市“揭榜挂 帅”科技项目（JBGS-008）

摘要：

目的　探讨H型高血压患者中性粒细胞/淋巴细胞比值（NLR）与臂踝脉搏波传导速度（baPWV） 的关系。方法　回顾性选取2022年延安大学咸阳医院心血管内科收治的262例H型高血压患者为研究对象。收集患 者一般资料和实验室检查指标。根据baPWV是否增快将患者分为正常组（baPWV＜1 800 cm/s， n=166）和增快组 （baPWV≥1 800 cm/s，n=96）。H型高血压患者baPWV增快的影响因素分析采用多因素Logistic回归分析，H型高血压 患者NLR与baPWV的相关性分析采用Pearson相关分析。结果　增快组年龄大于正常组，收缩压、舒张压、TG、空腹 血糖（FBG）、NLR高于正常组（P＜0.05）。多因素Logistic回归分析结果显示，年龄〔OR=1.174，95%CI（1.116， 1.235）〕、收缩压〔OR=1.051，95%CI（1.019，1.084）〕、舒张压〔OR=1.057，95%CI（1.005，1.112）〕、 TG〔OR=1.801，95%CI（1.188，2.731）〕、NLR〔OR=1.295，95%CI（1.026，1.635）〕是H型高血压患者baPWV 增快的独立影响因素（P＜0.05）。Pearson相关分析结果显示，H型高血压患者NLR与baPWV呈正相关（r=0.282， P＜0.001）。结论 NLR升高是H型高血压患者baPWV增快的危险因素，且NLR越高，baPWV越快，应引起临床医生 重视。

英文摘要：

　Objective To investigate the relationship between neutrophil to lymphocyte ratio (NLR) and brachial ankle pulse wave velocity (baPWV) in patients with H-type hypertension. Methods A total of 262 patients with H-type hypertension admitted to the Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University in 2022 were retrospectively selected as the study subjects. The general data and laboratory examination indexes of patients were collected. According to whether baPWV elevated, the patients were divided into normal group (baPWV < 1 800 cm/s, n=166) and elevated group (baPWV ≥ 1 800 cm/s, n=96) . Multivariate Logistic regression analysis was used to analyze the influencing factors of elevated baPWV in patients with H-type hypertension. Pearson correlation analysis was used to analyze the correlation between NLR and baPWV in patients with H-type hypertension. Results The age of the elevated group was older than that of the normal group, systolic blood pressure, diastolic blood pressure, TG, fasting blood glucose (FBG) and NLR were higher than those of the normal group (P < 0.05) . Multivariate Logistic regression analysis results showed that age [OR=1.174, 95%CI (1.116, 1.235) ] , systolic blood pressure [OR=1.051, 95%CI (1.019,1.084) ] , diastolic blood pressure [OR=1.057, 95%CI (1.005, 1.112) ] , TG [OR=1.801, 95%CI (1.188, 2.731) ] , NLR [OR=1.295, 95%CI (1.026, 1.635) ] were independent influencing factors of elevated baPWV in patients with H-type hypertension (P < 0.05) . Pearson correlation analysis results showed that NLR was positively correlated with baPWV in patients with H-type hypertension (r=0.282, P < 0.001) . Conclusion The increased NLR is a risk factor for the elevated baPWV in patients with H-type hypertension, and the higher the NLR, the faster the baPWV, which should be paid attention to by clinicians.

参考文献：