作者：王妍，闫巍，柯楠

单位：

1.100142北京市，海淀区玉渊潭社区卫生服务中心　2.100038北京市，首都医科大学附属复兴医院全科医学科

单位（英文）：

1.Yuyuantan Community Health Service Center, Beijing 100142, China 2.Department of General Medicine, Fuxing Hospital, Capital Medical University, Beijing 100038, China

关键词：

　肺疾病，慢性阻塞性；慢性阻塞性肺疾病前期；诊断；干预；综述

关键词（英文）：

Pulmonary disease, chronic obstructive; Pre-COPD; Diagnosis; Intervention; Review

中图分类号：

R 563.9

DOI：

10.12114/j.issn.1008-5971.2023.00.264

基金项目：

2022年度首都全科医学研究专项课题（22QK18）

摘要：

　慢性阻塞性肺疾病（COPD）是一种常见且严重的呼吸系统疾病，在全球范围内均具有较高的发病 率、致残率、致死率，对个体和社会造成了严重影响。然而，在COPD发生的前期阶段，即慢性阻塞性肺疾病前期 （Pre-COPD），患者可能仅出现轻微的呼吸道症状，肺功能尚未明显受损，若此时患者得到了及时诊治，可有效降 低COPD发病率。本文通过回顾相关文献，介绍了Pre-COPD的概念演变过程，指出其特征为患者存在早期肺部异常， 肺功能上表现为保留比值的肺功能减损，同时有肺结构性改变和/或生理异常，并进一步分析了其危险因素及潜在诊断 方法，同时指出其潜在干预策略（包括危险因素干预、肺康复及药物对症治疗等），这为Pre-COPD的预防和早期诊 断、干预提供了参考。

英文摘要：

Chronic obstructive pulmonary disease (COPD) is a common and serious respiratory disease, which has a high incidence rate, disability and mortality rates worldwide, and has a serious impact on individuals and society. However, in the early stage of COPD, which is Pre-COPD, patients may only experience mild respiratory symptoms and lung function has not been significantly damaged. If patients receive timely diagnosis and treatment at this time, it can effectively reduce the incidence of COPD. By reviewing relevant literature, this paper introduces the conceptual evolution of Pre-COPD and points out that it is characterized by early lung abnormalities, lung function impairment with retention ratio, lung structural changes and/or physiological abnormalities, and further analyzes its risk factors and potential diagnostic methods, and points out its potential intervention strategies (including risk factor intervention, pulmonary rehabilitation and drug symptomatic treatment) . This provides a reference for the prevention, early diagnosis and intervention of Pre-COPD.

参考文献：