作者：李豆，张维，曾军燕，张宏阁，梁欣怡，张绒

单位：

1.延安大学咸阳医院神经内科2.延安大学医学院3.眉山心脑血管病医院神经内科

单位（英文）：

1. Neurological Department, Xianyang Hospital Affiliated to Yan'an University, Xianyang 712000, China 2.Medical School of Yan'an University, Yan'an 716000, China 3.Neurological Department, Meishan Cardiovascular and Cerebrovascular Disease Hospital, Meishan 620000, China

关键词：

缺血性卒中; 睡眠呼吸暂停,阻塞性; 预后; 发病机制; 综述;

关键词（英文）：

Ischemic stroke; Sleep apnea, obstructive; Prognosis; Pathogenesis; Review

中图分类号：

DOI：

10.12114/j.issn.1008-5971.2023.00.166

基金项目：

2019年咸阳市重点研发项目（2019k02-106）；咸阳市2020年度中青年科技领军人才计划项目

摘要：

急性缺血性卒中（AIS）是一种急性脑血管病变，占所有新发卒中的81.9%。阻塞性睡眠呼吸暂停（OSA）是AIS的独立危险因素，其可通过多种复杂的病理生理机制使AIS发生风险增加3～4倍，并可能会进一步影响AIS的预后。近年来，国内外关于OSA对AIS预后影响的研究增多，但规范化治疗OSA对AIS患者神经功能恢复、心脑血管发病率和死亡率的影响近期才被探索。OSA仍是一种多见但缺乏诊疗的疾病，在中国AIS患者的OSA诊疗率仅为1%。本研究对OSA促进AIS发病的机制、OSA对AIS预后影响的研究现状和机制及规范化治疗OSA对AIS预后的影响进行阐述与总结，以期提高临床医师对AIS合并OSA患者的诊治水平，并为进一步研究OSA对AIS预后的影响提供可靠依据。

英文摘要：

Acute ischemic stroke (AIS) is an acute cerebrovascular disease, accounting for 81.9% of all new strokes. Obstructive sleep apnea (OSA) is an independent risk factor for AIS, which can increase the risk of AIS by 3-4 times through a variety of complex pathophysiological mechanisms, and may further affect the prognosis of AIS. In recent years, the research on the effect of OSA on the prognosis of AIS has increased, but the effect of standardized treatment of OSA on the recovery of neurological function, cardiovascular and cerebrovascular morbidity and mortality of AIS has only been explored recently. OSA is still a common disease but lacks diagnosis and treatment. The diagnosis and treatment rate of OSA in AIS patients in China is only 1%. In this study, the mechanism of OSA promoting the occurrence of AIS, the research status and mechanism of the influence of OSA on the prognosis of AIS, and the influence of standardized treatment of OSA on the prognosis of AIS were elaborated and summarized, in order to improve the standardized diagnosis and treatment of AIS patients with OSA, and provide a reliable basis for further study of the influence of OSA on the prognosis of AIS.

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