作者：岳红云，李世元，罗园，李玉雪

单位：

1.河北省石家庄市人民医院呼吸内科2.河北省石家庄市人民医院检验科

单位（英文）：

1.DepartmentofRespiratoryMedicine,ShijiazhuangPeople'sHospital,Shijiazhuang050000,China2.DepartmentofInspection,ShijiazhuangPeople'sHospital,Shijiazhuang050000,China

关键词：

肺肿瘤; 碱性成纤维细胞生长因子; 临床病理特征; 预后;

关键词（英文）：

Lungneoplasms;Basicfibroblastgrowthfactor;Clinicopathologicalfeatures;Prognosis

中图分类号：

R734.2

DOI：

10.12114/j.issn.1008-5971.2023.00.064

基金项目：

石家庄市科技局课题( 171461303?)

摘要：

目的 分析肺癌患者血清碱性成纤维细胞生长因子(b-FGF)与临床病理特征、预后的相关性。方法选取2020年1月至2021年1月在石家庄市人民医院住院的60例肺癌患者作为观察组，另选取同期在石家庄市人民医院门诊体检的60例体检健康者作为对照组。比较观察组和对照组、不同临床病理特征患者、存活和死亡患者血清b-FGF；肺癌患者血清b-FGF与临床病理特征的相关性分析采用Spearman秩相关分析。结果 观察组血清b-FGF高于对照组(P<0.05)。不同肿瘤直径、分化程度、TNM分期及有无淋巴结转移患者血清b-FGF比较，差异有统计学意义(P<0.05)。死亡患者血清b-FGF高于存活患者(P<0.05)。Spearman秩相关分析结果显示，肺癌患者血清b-FGF与肿瘤直径(rs=0.485,P=0.037)、TNM分期(rs=0.578,P=0.009)、淋巴结转移(rs=0.601,P=0.003)呈正相关，与分化程度呈负相关(rs=-0.512,P=0.014)。结论 肺癌患者血清b-FGF呈高表达，且血清b-FGF与肺癌患者临床病理特征及预后不良有关。

英文摘要：

ObjectiveToanalyzetherelationshipbetweenserumbasicfibroblastgrowthfactor(b-FGF)andclinicopathologicalfeaturesandprognosisinpatientswithlungcancer.MethodsSixtypatientswithlungcancerwhowerehospitalizedinShijiazhuangPeople'sHospitalfromJanuary2020toJanuary2021wereselectedastheobservationgroup,and60healthypeoplewhounderwentphysicalexaminationinShijiazhuangPeople'sHospitalatthesametimewereselectedasthecontrolgroup.Serumb-FGFwascomparedbetweentheobservationgroupandthecontrolgroup,inpatientswithdifferentclinicopathologicalfeatures,betweensurvivalpatientsanddeadpatients;Spearmanrankcorrelationanalysiswasusedtoanalyzethecorrelationbetweenserumb-FGFandclinicopathologicalfeaturesinpatientswithlungcancer.ResultsTheserumb-FGFintheobservationgroupwashigherthanthatinthecontrolgroup(P<0.05).Thereweresignificantdifferencesinserumb-FGFamongpatientswithdifferenttumordiameter,differentiationdegree,TNMstageandwithorwithoutlymphnodemetastasis(P<0.05).Theserumb-FGFinthedeadpatientswashigherthanthatinthesurvivalpatients(P<0.05).Spearmanrankcorrelationanalysisshowedthatserumb-FGFwaspositivelycorrelatedwithtumordiameter(rs=0.485,P=0.037),TNMstage(rs=0.578,P=0.009)andlymphnodemetastasis(rs=0.601,P=0.003),andnegativelycorrelatedwithdifferentiationdegree(rs=-0.512,P=0.014).ConclusionSerumb-FGFishighlyexpressedinpatientswithlungcancer,andserumb-FGFisassociatedwithclinicopathologicalfeaturesandpoorprognosisinpatientswithlungcancer.

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