作者：蔡宇豪1 ，惠波2 ，宋小龙3 ，管军2 ，戴红艳2 ，邵一兵2 ，侯雪梅4

单位：

1.266000山东省青岛市第八人民医院心内科　2.266000山东省青岛市市立医院东院区心内一科　3.266000山 东省青岛市市立医院急诊科　4.250012山东省济南市中医医院心内科

Units：

1.Department of Cardiology, Qingdao Eighth People's Hospital, Qingdao 266000, China 2.Department of Cardiology, East Hospital of Qingdao Municipal Hospital, Qingdao 266000, China 3.Department of Emergency, Qingdao Municipal Hospital, Qingdao 266000, China 4.Department of Cardiology, Jinan Traditional Chinese Medicine Hospital, Jinan 250012, China

关键词：

冠心病；血管内皮生长因子；基因多态性

Keywords：

Coronary disease; Vascular endothelial growth factor; Gene polymorphism

CLC：

R 541.4

DOI：

10.12114/j.issn.1008-5971.2024.00.035

Funds：

山东省中医药科技项目（2021M122）

摘要：

　目的　探讨血管内皮生长因子（VEGF）基因rs1570360、rs3025039位点多态性与冠心病患者冠状动 脉多支病变的相关性。方法　选取2016年1月—2018年1月青岛市市立医院收治的冠心病患者286例为研究对象，根 据冠状动脉病变支数将其分为单支病变组（153例）和多支病变组（133例）。收集患者的临床资料，检测VEGF基 因rs1570360、rs3025039位点多态性，采用多因素Logistic回归分析探讨冠心病患者冠状动脉多支病变的影响因素。 结果　多支病变组男性占比、有吸烟史者占比、有高血压史者占比、有糖尿病史者占比、有高脂血症史者占比、有 冠心病家族史者占比、低密度脂蛋白胆固醇（LDL-C）、丙氨酸氨基转移酶（ALT）高于单支病变组，年龄大于单 支病变组，BMI低于单支病变组（P＜0.05）。两组VEGF基因rs1570360位点等位基因频率比较，差异有统计学意义 （P＜0.05）。多因素Logistic回归分析结果显示，年龄、BMI、吸烟史、糖尿病史、LDL-C是冠心病患者冠状动脉多支 病变的独立影响因素（P＜0.05）。结论　本研究并未发现VEGF基因rs1570360、rs3025039位点多态性是冠心病患者冠 状动脉多支病变的影响因素，而年龄增大、有吸烟史、有糖尿病病史、LDL-C升高是冠心病患者冠状动脉多支病变的 危险因素，BMI升高是冠心病患者冠状动脉多支病变的保护因素。

Abstract：

Objective To explore the correlation between polymorphisms of rs1570360 and rs3025039 loci of vascular endothelial growth factor (VEGF) gene and coronary multi-vessel disease in patients with coronary heart disease. Methods A total of 286 patients with coronary heart disease admitted to the Qingdao Municipal Hospital from January 2016 to January 2018 were selected as the research objects. The patients were divided into single-vessel lesion group (153 cases) and multi-vessel lesion group (133 cases) based on the number of coronary artery lesions. The clinical data of the patients were collected, and the polymorphisms of rs1570360 and rs3025039 loci of VEGF gene were detected. Multivariate Logistic regression analysis was used to explore the influencing factors of coronary multi-vessel disease in patients with coronary heart disease. Results The proportion of male, proportion of patients with smoking history, proportion of patients with hypertension history, proportion of patients with diabetes history, proportion of patients with hyperlipidemia history, proportion of patients with family of coronary heart disease, low density lipoprotein cholesteroll (LDL-C) , alanine aminotransferase (ALT) in the multi-vessel disease group were higher than those in the single-vessel disease group, age in the multi-vessel disease group was older than that in the single-vessel disease group, and BMI in the multi-vessel disease group was lower than that in the single-vessel disease group (P < 0.05) . There were significant differences in the allele frequency of rs1570360 loci between the two groups (P < 0.05) . Multivariate Logistic regression analysis showed that age, BMI, smoking history, diabetes history and LDL-C were the independent influencing factors of coronary multi-vessel disease in patients with coronary heart disease (P < 0.05) . Conclusion This paper doesn't find that polymorphisms of rs1570360 and rs3025039 loci of VEGF gene are the influencing factors of coronary multi-vessel disease in patients with coronary heart disease. Increased age, smoking history, diabetes history and increased LDL-C are the risk factors of coronary multi-vessel disease in patients with coronary heart disease, increased BMI is a protective factor of coronary multi-vessel disease in patients with coronary heart disease.

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