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2024-5-25
Vol 32, issue 5

ISSUE

2023 年3 期 第31 卷

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三酰甘油-葡萄糖指数与缺血性卒中患者发生轻度认知障碍的关系分析

RelationshipbetweenTriglyceride-GlucoseIndexandMildCognitiveImpairmentinPatientswithIschemicStroke

作者:陈晋莉,吴权,陈礼龙,王辉

单位:
上海市金山区亭林医院神经内科
Units:
DepartmentofNeurology,JinshanDistrictTinglinHospital,Shanghai201500,China
关键词:
缺血性卒中; 认知功能障碍; 三酰甘油-葡萄糖指数;
Keywords:
Ischemicstroke;Cognitivesysfunction;Triglyceride-glucoseindex
CLC:
R743.3R741
DOI:
10.12114/j.issn.1008-5971.2023.00.070
Funds:

摘要:

目的 分析三酰甘油-葡萄糖(TyG)指数与缺血性卒中患者发生轻度认知障碍(MCI)的关系。方法选取2020—2021年于上海市金山区亭林医院住院的缺血性卒中患者256例。收集患者一般资料,根据入院时TyG指数的中位数将患者分为低TyG指数组(TyG指数<8.55)(n=126)和高TyG指数组(TyG指数≥8.55)(n=130)。所有患者于出院后1个月完成第1次门诊随访,出院后半年至1年完成第2次门诊随访,随访期间至少完成1次认知功能评估,主要结局事件为随访期间发生MCI。采用Kaplan-Meier法绘制不同TyG指数缺血性卒中患者发生MCI的生存曲线,并采用Log-rank检验分析其差异。采用多因素Cox比例风险回归分析探讨TyG指数与缺血性卒中患者发生MCI的关系。结果 高TyG指数组BMI、入院时三酰甘油、入院时空腹血糖、有糖尿病史者占比高于低TyG指数组,入院时HDL-C低于低TyG指数组(P<0.05)。本研究随访中位时间为9.2个月。高TyG指数组累积MCI发生率高于低入院TyG指数组(P<0.05)。多因素Cox比例风险回归分析结果显示,TyG指数≥8.55是缺血性卒中患者发生MCI的危险因素(P<0.05)。结论 TyG指数≥8.55是缺血性卒中患者发生MCI的独立危险因素。

Abstract:

ObjectiveToanalyzetherelationshipbetweentriglyceride-glucose(TyG)indexandmildcognitiveimpairment(MCI)inpatientswithischemicstroke.MethodsAtotalof256patientswithischemicstrokeadmittedtoJinshanDistrictTinglinHospitalfrom2020to2021wereselected.Thegeneraldataofpatientswerecollected.AccordingtothemedianvalueofTyGindexatadmission,thepatientsweredividedintolowTyGindexgroup(TyGindex<8.55)(n=126)andhighTyGindexgroup(TyGindexN 8.55)(n=130).Allpatientscompletedthefirstoutpatientfollow-upat1monthafterdischarge,andthesecondoutpatientfollow-upat6monthsto1yearafterdischarge.Duringthefollow-up,atleastonecognitivefunctionassessmentwascompleted.ThemainoutcomeeventwasMCIduringthefollow-up.Kaplan-MeiermethodwasusedtodrawthesurvivalcurvesofMCIinischemicstrokepatientswithdifferentTyGindex,andLog-ranktestwasusedtoanalysetheirdifferences.MultivariateCoxproportionalregressionanalysiswasusedtoinvestigatetherelationshipbetweenTyGindexandMCIinpatientswithischemicstroke.ResultsBMI,triglycerideonatadmission,fastingbloodglucoseatadmission,andtheproportionofpatientswithhistoryofdiabetesinthehighTyGindexgroupwerehigherthanthoseinthelowTyGindexgroup,andHDL-CatadmissionwaslowerthanthatinthelowTyGindexgroup(P<0.05).Themedianfollow-uptimeofthisstudywas9.2months.TheincidenceofcumulativeMCIinhighTyGindexgroupwashigherthanthatinlowTyGindexgroup(P<0.05).MultivariateCoxproportionalriskregressionanalysisshowedthatTyGindexN 8.55wasariskfactorforMCIinischemicstrokepatients(P<0.05).ConclusionTyGindexN 8.55isanindependentriskfactorforMCIinpatientswithischemicstroke.

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