作者：石会

单位：

河北省石家庄市中医院内一科

Units：

Department of Medicine, Shijiazhuang Hospital of Traditional Chinese Medicine;

关键词：

脑梗死; 丘脑; 四肢麻木; 肢体麻木; 灯银脑通胶囊; 井穴放血疗法; 治疗结果; 同型半胱氨酸; 胰岛素样生长因子Ⅱ;

Keywords：

Brain infarction;Thalamus;Numbness of extremities;Paraesthesia;Dengyinnaotong capsule;Well point bloodletting therapy;Treatment outcome;Homocysteine;Insulin-like growth factor Ⅱ;

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.283

Funds：

河北省中医药管理局科研计划项目（2022170）；

摘要：

目的 分析灯银脑通胶囊联合井穴放血疗法治疗丘脑梗死所致肢体麻木的临床疗效及其对患者血清同型半胱氨酸（Hcy）、胰岛素样生长因子（IGF）Ⅱ水平的影响。方法 选取2019年4月至2021年1月石家庄市中医院脑病一科门诊接收的丘脑梗死患者80例为研究对象。采用随机数字表法将患者分为治疗组和对照组，各40例。对照组采用井穴放血疗法治疗，治疗组采用灯银脑通胶囊联合井穴放血疗法治疗。比较两组患者治疗前、治疗1个疗程后、治疗2个疗程后感觉障碍评定积分表评分，临床疗效，治疗前、治疗1个疗程后、治疗2个疗程后血清Hcy、IGFⅡ水平。结果治疗组患者治疗1、2个疗程后感觉障碍评定积分表评分低于对照组（P<0.05）；对照组、治疗组患者治疗1、2个疗程后感觉障碍评定积分表评分分别低于本组治疗前，治疗2个疗程后感觉障碍评定积分表评分分别低于本组治疗1个疗程后（P<0.05）。治疗组患者临床疗效优于对照组（P<0.05）。治疗组患者治疗1、2个疗程后血清Hcy水平低于对照组，治疗1个疗程后IGFⅡ水平低于对照组（P<0.05）；对照组、治疗组患者治疗1、2个疗程后血清Hcy、IGFⅡ水平分别低于本组治疗前，治疗2个疗程后血清Hcy、IGFⅡ水平分别低于本组治疗1个疗程后（P<0.05）。结论 灯银脑通胶囊联合井穴放血疗法可有效减轻丘脑梗死所致肢体麻木患者的麻木症状，提高其临床疗效，其机制可能与其可降低患者血清Hcy、IGFⅡ水平，进而减轻炎症反应、改善神经功能有关。

Abstract：

Objective To analyze the clinical efficacy of Dengyinnaotong capsule combined with well point bloodletting therapy in the treatment of limb numbness caused by thalamic infarction and its effect on serum homocysteine（Hcy） and insulin-like growth factor（IGF） Ⅱ levels. Methods A total of 80 patients with thalamic infarction received from the Outpatient Department of the First Department of Encephalopathy, Shijiazhuang Hospital of Traditional Chinese Medicine from April 2019 to January 2021 were selected as the research objects. The patients were divided into treatment group and control group by random number table method, 40 cases in each group. The control group was treated with well point bloodletting therapy, while the treatment group was treated with Dengyinnaotong capsule combined with well point bloodletting therapy. The scores of sensory disturbance assessment score table before treatment, after 1 course of treatment and after 2 courses of treatment, clinical efficacy, the levels of serum Hcy and IGFⅡ before treatment, after 1 course of treatment and after 2 courses of treatment were compared between the two groups. Results After 1 and 2 courses of treatment, the score of sensory disturbance assessment score table in the treatment group was lower than that in the control group（P < 0.05）; after 1 and 2 courses of treatment in the control group and the treatment group, the scores of the sensory disturbance assessment score table were lower than those before treatment, and the scores of the sensory disturbance assessment score table after 2 courses of treatment were lower than those after 1 course of treatment, respectively（P < 0.05）. The clinical efficacy of the treatment group was better than that of the control group（P < 0.05）. The serum Hcy level after 1 and 2 courses of treatment in the treatment group was lower than that in the control group, and the IGFⅡ level after 1 course of treatment was lower than that in the control group（P < 0.05）; in the control group and the treatment group, the levels of serum Hcy and IGFⅡ after 1 and 2 courses of treatment were lower than those before treatment, and the levels of serum Hcy and IGFⅡ after 2 courses of treatment were lower than those after 1 course of treatment, respectively（P < 0.05）. Conclusion Dengyinnaotong capsule combined with well point bloodletting therapy can effectively reduce the numbness symptoms of patients with limb numbness caused by thalamic infarction and improve their clinical efficacy. The mechanism may be related to the fact that it can reduce the serum Hcy and IGFⅡ levels of patients, thereby reducing inflammatory reactions and improving neural function.

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