作者：潘娜娜，潘家华，毛国顺，叶玉兰，朱影

单位：

1.236000安徽省阜阳市人民医院儿科 2.230001安徽省合肥市，中国科学技术大学附属第一医院新生儿科 通信作者：潘家华，E-mail：panjiahua1960@163.com

Units：

1.Department of Pediatrics, Fuyang People's Hospital, Fuyang 236000, China 2.Department of Neonatology, the First Affiliated Hospital of USTC, Hefei 230001, China Corresponding author: PAN Jiahua, E-mail: panjiahua1960@163.com

关键词：

呼吸窘迫综合征,新生儿; 早产儿; 微创注入肺表面活性物质; 气管插管-肺表面活性物质-拔管; 治疗结果;

Keywords：

Respiratory distress syndrome, newborn; Premature infant; Less invasive surfactant administration;Intubation-surfactant-extubation; Treatment outcome

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.176

Funds：

安徽省中央引导地方科技发展科技创新项目（201707d08050005）

摘要：

目的 比较微创注入肺表面活性物质(LISA)技术与气管插管-肺表面活性物质-拔管(INSURE)技术治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法 选取2019年12月至2021年1月阜阳市人民医院新生儿重症监护室收治的54例NRDS患儿为研究对象。采用随机数字表法将其分为LISA组和INSURE组,每组27例。LISA组在常规治疗的基础上采用LISA技术治疗,INSURE组在常规治疗的基础上采用INSURE技术治疗。比较两组患儿一般资料、用药过程相关指标[包括插管所需时间和用药过程中经皮动脉血氧饱和度(SpO2)下降、心动过缓、药物反流发生情况及再次使用肺表面活性物质(PS)、72 h内机械通气情况]、并发症发生情况、无创通气时间、住院时间。结果 LISA组患儿插管所需时间短于INSURE组,用药过程中SpO2下降、心动过缓、药物反流、72 h内机械通气者占比低于INSURE组(P<0.05)。LISA组患儿并发症发生率低于INSURE组,无创通气时间、住院时间短于INSURE组(P<0.05)。结论相比于传统的INSURE技术,LISA技术可缩短NRDS患儿插管所需时间、无创通气时间、住院时间,降低机械通气使用率、并发症发生率,值得临床推广。

Abstract：

【Abstract】 Objective To compare the efficacy of less invasive surfactant administration (LISA) technology andintubation-surfactant-extubation (INSURE) technology in the treatment of neonatal respiratory distress syndrome (NRDS) .MethodsA total of 54 children with NRDS admitted to the Neonatal Intensive Care Unit of Fuyang People's Hospital fromDecember 2019 to January 2021 were selected as the research objects. They were divided into LISA group and INSURE group byrandom number table method, 27 cases in each group. The LISA group was treated with LISA technology based on the conventionaltherapy, and the INSURE group was treated with INSURE technology based on the conventional therapy. The general data, relatedindicators of the medication process [including the time required for intubation, the incidence of percutaneous arterial oxygensaturation (SpO2) decrease, bradycardia, drug reflux, re-use of pulmonary surfactant (PS) , and mechanical ventilation within 72hours] during the medication process, complications, non-invasive ventilation time, hospitalization time of the two groups werecompared.ResultsThe time required for intubation of the children in the LISA group was shorter than that in the INSUREgroup, and the proportions of SpO2 decrease, bradycardia, drug reflux, and mechanical ventilation within 72 hours were lowerthan those in the INSURE group (P < 0.05) . The incidence of complications in the LISA group was lower than that in the INSUREgroup, and the non-invasive ventilation time and hospitalization time were shorter than those in the INSURE group (P < 0.05) .Conclusion Compared with the traditional INSURE technology, LISA technology can shorten the time required for intubation, noninvasive ventilation, and hospitalization time in children with NRDS, reduce the use of mechanical ventilation, and the incidence ofcomplications. It is worthy of clinical promotion.

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