作者：房辉，高芳兰，任彩丽，沈茜茜，卞丽丽

单位：

1.214151江苏省无锡市同仁康复医院康复治疗科 2.214151江苏省无锡市同仁康复医院神经康复科 通信作者：房辉，E-mail：f13306186953@163.com

Units：

1.Department of Rehabilitation Therapy, Wuxi Tongren Rehabilitation Hospital, Wuxi 214151, China 2.Department of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi 214151, China Corresponding author: FANG Hui, E-mail: f13306186953@163.com

关键词：

卒中; 失语症; 强制诱导性语言疗法; 额叶; 经颅直流电刺激; 治疗结果;

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.141

Funds：

国家自然科学基金青年科学基金项目（81501949）

摘要：

目的 探究双额叶在线经颅直流电刺激（tDCS）联合强制诱导性语言疗法在卒中后亚急性期失语症患者中的应用效果。方法 选取2016年8月至2021年3月无锡市同仁康复医院收治的78例卒中后亚急性期失语症患者作为研究对象，采用随机数字表法将其分为A、B、C组，每组26例。A组予以强制诱导性语言疗法，B组予以双额叶tDCS,C组予以双额叶在线tDCS联合强制诱导性语言疗法；三组均维持治疗4周后评估疗效。比较三组患者治疗前后西方失语症成套测验（WAB）评分，临床疗效，治疗前后图片命名测试评分和脑神经功能指标。结果 治疗后，三组患者自发言语、复述、命名评分及失语指数分别高于本组治疗前，且C组患者高于A、B组（P<0.05）。C组患者临床疗效优于A、B组（P<0.05）。治疗后，三组患者图片命名测试评分分别高于本组治疗前，左额F3、左前颞T3、左中央区C3(δ+θ)/（α+β）相对功率比分别低于本组治疗前，且C组患者图片命名测试评分高于A、B组，左额F3(δ+θ)/（α+β）相对功率比低于A、B组（P<0.05）。结论 双额叶tDCS、强制诱导性语言疗法均能有效改善卒中后亚急性期失语症患者语言功能、图片命名能力及脑神经功能，而双额叶在线tDCS联合强制诱导性语言疗法对患者临床疗效的提高及语言功能、图片命名能力、脑神经功能的改善效果更明显。

Abstract：

【Abstract】 Objective To explore the effect of dual frontal online transcranial direct current stimulation (tDCS)combined with constraint-induced aphasia therapy in patients with subacute aphasia after stroke. Methods A total of 78 patientswith subacute aphasia after stroke treated in the Wuxi Tongren Rehabilitation Hospital from August 2016 to March 2021 wereselected as the research objects, they were divided into groups A, B and C by random number table method , with 26 cases in eachgroup. Group A was treated with constraint-induced aphasia therapy, group B was treated with dual frontal tDCS, and group C wastreated with dual frontal online tDCS combined with constraint-induced aphasia therapy; the curative effect of the three groupswas evaluated after 4 weeks of maintenance treatment. The scores of Western Aphasia Battery (WAB) before and after treatment,clinical efficacy, picture naming test scores and brain nerve function indexes before and after treatment were compared among thethree groups. Results After treatment, the scores of spontaneous speech, repetition, naming and aphasia quotient in the threegroups were higher than those before treatment, and those in group C were higher than those in group A and group B (P < 0.05) .The clinical efficacy of group C was better than that of group A and group B (P < 0.05) . After treatment, the scores of picturenaming test in the three groups were higher than those before treatment, (δ+θ) / (α+β) relative power ratio of left frontal F3,left anterior temporal T3 and left central area C3 in the three groups after treatment were lower than those before treatment, andthe score of picture naming test in group C was higher than that in group A and group B, (δ+θ) / (α+β) relative power ratio ofleft frontal F3 in group C was lower than that in group A and group B (P < 0.05) .ConclusionDual frontal tDCS, constraintinduced aphasia therapy can effectively improve the language function, picture naming ability and brain nerve function of patientswith subacute aphasia after stroke, while dual frontal online tDCS combined with constraint-induced aphasia therapy can moresignificantly improve the clinical efficacy,language function,picture naming ability and brain nerve function of patients.

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