作者：张莉，沈莉

单位：

441300 湖北省随州市，湖北医药学院附属随州医院（随州市中心医院）；通信作者：沈莉，E-mail：shenlicv@126.com

Units：

Suizhou Hospital Affiliated to Hubei University of Medicine（the Central Hospital of Suizhou），Suizhou 441300，China；Corresponding author：SHEN Li，E-mail：shenlicv@126.com

关键词：

卒中；失语症；经颅直流电刺激；记忆强化训练；应用效果

Keywords：

Stroke；Aphasia；Transcranial direct current stimulation；Intensive memory training；Application effect

CLC：

R 743　R 767.64

DOI：

DOI：10.3969/j.issn.1008-5971.2020.01.016

Funds：

摘要：

目的　观察经颅直流电刺激（tDCS）联合记忆强化训练治疗缺血性脑卒中后失语症患者的临床效果。方法　选取 2017 年 3 月—2018 年 3 月随州市中心医院神经内科收治的缺血性脑卒中后失语症患者 82 例，采用随机数字表法分为对照组和研究组，每组 41 例。对照组患者采用 tDCS 假刺激联合记忆强化训练，研究组患者采用 tDCS 联合记忆强化训练；两组患者均持续治疗 1 个月。比较两组患者治疗前后西方失语症成套测验（WAB）评分及临床效果、治疗满意度，并观察两组患者治疗期间不良反应发生情况。结果　（1）两组患者治疗前自发言语、听理解、复述、命名、失语商（AQ）评分及治疗后听理解评分比较，差异无统计学意义（P>0.05）；研究组患者治疗后自发言语、复述、命名及 AQ 评分高于对照组（P<0.05）。（2）研究组患者临床效果、治疗满意度优于对照组（P<0.05）。（3）两组患者治疗期间均未出现严重不良反应。结论　tDCS 联合记忆强化训练治疗缺血性脑卒中后失语症患者的临床效果确切，可有效改善患者语言功能，提高患者治疗满意度，且安全性较高。

Abstract：

Objective　To observe the clinical effect of transcranial direct current stimulation（tDCS）combined withmemory intensive training in treating ischemic stroke patients complicated with aphasia. Methods　From March 2017 to March2018，a total of 82 ischemic stroke patients complicated with aphasia were selected in the Department of Neurology，the CentralHospital of Suizhou，and they were divided into control group and study group according to random number table method，with41 cases in each group. Patients in control group received sham tDCS combined with memory intensive training，while patientsin study group received tDCS combined with memory intensive training；both groups were continuously treated for 1 month.Western Aphasia Battery Test（WAB）score before and after treatment，as well as clinical effect and treatment satisfaction werecompared between the two groups，moreover incidence of adverse reactions was observed during treatment. Results　（1）There was no statistically significant difference of spontaneous speech score，auditory comprehension score，retelling score，naming score or aphasia quotient（AQ）score before treatment as well as auditory comprehension score after treatment betweenthe two groups（P>0.05），while spontaneous speech score，retelling score，naming score and AQ score in study groupwere statistically significantly higher than those in control group after treatment（P<0.05）.（2）Clinical effect and treatmentsatisfation in study group were significantly better than those in control group（P<0.05）.（3）No one in the two groups occurredany serious adverse reactions during treatment. Conclusion　In ischemic stroke patients complicated with aphasia，tDCScombined with memory intensive training performs certain clinical effect，which can effectively improve the language functionand promote treatment satisfaction，with relatively high safety.

ReferenceList：